Measles Virus Infection Synergizes with IL-4

IgE Class Switching Measles Virus Infection Synergizes with IL-4

Interactions of  Viruses with Dendritic Cells: A Double-edged Sword

D iverse mechanisms are used by viruses to inhibit, block, or evade the immune response (see review in reference 1). These include reduced expression of critical antigenic epitopes (e.g., EBV in latency), genetic variation of class I–restricted CTL epitopes (HIV-1), clonal exhaustion of CTLs (HIV-1, lymphocytic choriomeningitis virus), downregulation of MHC class I and peptide–MHC complex expre...

Buthionine Sulfoximine Inhibits Cytopathic Effects and Apoptosis Induced by Infection with AIK-HDC Strain of Measles Virus

Measles virus (MV) is a highly contagious agent which causes a major health problem in developing countries. We studied the effect of buthionine sulfoximine (BSO) on the replication of an AIK-HDC strain of MV and its induced apoptosis in Vero cell lines. Methods: In this study, toxicity of BSO on Vero cells was investigated first, resulted in determination of sub-lethal or non-toxic concentrati...

Measles virus infection in adults induces production of IL-10 and is associated with increased CD4+ CD25+ regulatory T cells.

Despite steady progress in elimination of measles virus globally, measles infection still causes 500,000 annual deaths, mostly in developing countries where endemic measles strains still circulate. Many adults are infected every year in China, with symptoms more severe than those observed in children. In this study, we have used blood samples from adult measles patients in Shanghai and age-matc...

Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans.

BACKGROUND Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. METHODS BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts ...